List of therapeutic monoclonal antibodies

Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies.

The abbreviations in the column Type are as follows:

• mab: whole monoclonal antibody
• Fab: fragment, antigen-binding (one arm)
  • F(ab')₂: fragment, antigen-binding, including hinge region (both arms)
  • Fab': fragment, antigen-binding, including hinge region (one arm)
• Variable fragments:
  • scFv: single-chain variable fragment
  • di-scFv: dimeric single-chain variable fragment
  • sdAb: single-domain antibody
• BsAb: bispecific monoclonal antibody:
  • 3funct: trifunctional antibody
  • BiTE: bi-specific T-cell engager

This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.