Varlilumab
| Monoclonal antibody | |
|---|---|
| Type | ? |
| Source | Human |
| Target | CD27 |
| Clinical data | |
| Other names | CDX-1127 |
| ATC code |
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| Identifiers | |
| CAS Number | |
| ChemSpider |
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| UNII | |
| Chemical and physical data | |
| Formula | C6486H9992N1740O2022S42 |
| Molar mass | 146043.96 g·mol−1 |
Varlilumab (INN; development code CDX-1127) is a monoclonal antibody designed for immunotherapy for solid tumors and hematologic malignancies. It is an anti-CD27 antibody and helps activate T-cells.
This drug was developed by Celldex Therapeutics.
It (in combination with ONT-10) has undergone a phase 1B clinical trial for advanced breast or ovarian cancer. In combination with anti-PD-1 nivolumab it has undergone a phase 1/2 trial for advanced refractory solid tumours