TXNDC12

TXNDC12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SEN, 2K8V
Identifiers
Aliases	TXNDC12, AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12
External IDs	OMIM: 609448; MGI: 1913323; HomoloGene: 41074; GeneCards: TXNDC12; OMA:TXNDC12 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	52,055,191 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	108,719,324 bp
RNA expression pattern
	Top expressed in
	monocyte; ; rectum; ; gonad; ; stromal cell of endometrium; ; body of pancreas; ; islet of Langerhans; ; ventricular zone; ; placenta; ; gallbladder; ; olfactory zone of nasal mucosa;
	Top expressed in
	medial ganglionic eminence; ; spermatocyte; ; endocardial cushion; ; dermis; ; calvaria; ; epithelium of lens; ; atrium; ; efferent ductule; ; atrioventricular valve; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; protein-disulfide reductase (glutathione) activity; protein binding;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum;
Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cell redox homeostasis; cell differentiation; negative regulation of cell death;
	Sources:Amigo / QuickGO
Orthologs
	51060
	66073
	ENSG00000117862
	ENSMUSG00000028567
	O95881
	Q9CQU0
	NM_015913
	NM_025334
	NP_056997
	NP_079610
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors (Liu et al., 2003).[supplied by OMIM]