CXXC1

CXXC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QMB, 3QMC, 3QMD, 3QMG, 3QMH, 3QMI
Identifiers
Aliases	CXXC1, 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP, CXXC finger protein 1
External IDs	OMIM: 609150; MGI: 1921572; HomoloGene: 32221; GeneCards: CXXC1; OMA:CXXC1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,287,839 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	74,354,567 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; body of pancreas; ; right uterine tube; ; pancreatic ductal cell; ; granulocyte; ; right lobe of thyroid gland; ; skin of leg; ; sural nerve; ; skin of abdomen; ; left lobe of thyroid gland;
	Top expressed in
	Ileal epithelium; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; choroid plexus of fourth ventricle; ; lactiferous gland; ; entorhinal cortex; ; perirhinal cortex; ; secondary oocyte; ; otic vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; protein binding; cis-regulatory region sequence-specific DNA binding; histone methyltransferase activity (H3-K4 specific); metal ion binding; unmethylated CpG binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear matrix; nuclear speck; nucleus; nucleoplasm; histone methyltransferase complex; cytosol; Set1C/COMPASS complex;
Biological process	positive regulation of transcription, DNA-templated; IRE1-mediated unfolded protein response; histone H3-K4 methylation; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	30827
	74322
	ENSG00000154832
	ENSMUSG00000024560
	Q9P0U4
	Q9CWW7
	NM_001101654; NM_014593
	NM_028868; NM_001378844
	NP_001095124; NP_055408
	NP_083144; NP_001365773
	Wikidata
View/Edit Human	View/Edit Mouse

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.