Mometasone

Mometasone
Clinical data
Trade names	Nasonex, Asmanex, Elocon, others
Other names	LAS-41002, 9α,21-Dichloro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17α-(2-furoate)
AHFS/Drugs.com	Monograph
License data	US DailyMed: Mometasone;
Pregnancy; category	AU: B3;
Routes of; administration	Topical, inhalation (nasal spray)
Drug class	Corticosteroid; Glucocorticoid
ATC code	D07AC13 (WHO) R01AD09 (WHO), R03BA07 (WHO);
Legal status
Legal status	AU: S2 (Pharmacy medicine) / S4; CA: ℞-only; US: ℞-only / OTC; EU: Rx-only;
Pharmacokinetic data
Bioavailability	Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone
Protein binding	98% to 99%
Metabolism	Liver
Elimination half-life	5.8 hours
Identifiers
	IUPAC name (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate;
CAS Number	105102-22-5 83919-23-7;
PubChem CID	441335; as furoate: 441336;
DrugBank	DB00764 ; as furoate: DB14512;
ChemSpider	390090 ; as furoate: 390091;
UNII	8HR4QJ6DW8; as furoate: 04201GDN4R;
KEGG	D08227; as furoate: D00690;
ChEBI	CHEBI:6970 ; as furoate: CHEBI:47564;
ChEMBL	ChEMBL1201404 ; as furoate: ChEMBL1161;
CompTox Dashboard (EPA)	DTXSID4023333 ;
ECHA InfoCard	100.125.600
Chemical and physical data
Formula	C22H28Cl2O4 for mometasone; C27H30O6Cl2 as furoate
3D model (JSmol)	Interactive image; as furoate: Interactive image;
	SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)O)C)O)Cl)C; ; as furoate: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C;
	InChI InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:QLIIKPVHVRXHRI-CXSFZGCWSA-N ; ; as furoate: InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1; Key:WOFMFGQZHJDGCX-ZULDAHANSA-N;
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Mometasone, also known as mometasone furoate, is a steroid (specifically, a glucocorticoid) medication used to treat certain skin conditions, hay fever, and asthma. Specifically it is used to prevent rather than treat asthma attacks. It can be applied to the skin, inhaled, or used in the nose. Mometasone furoate, not mometasone, is used in medical products.

Common side effects when used for asthma include headache, sore throat, and thrush. It is therefore recommended to rinse the mouth after use. Long-term use may increase the risk for glaucoma and cataracts. Common side effects when used in the nose include upper respiratory tract infections and nose bleeds. Common side effects when applied on the skin include acne, skin atrophy, and itchiness. It works by decreasing inflammation.

Mometasone furoate was patented in 1981 and came into medical use in 1987. It is on the World Health Organization's List of Essential Medicines and is available as a generic medication. In 2022, it was the 311th most commonly prescribed medication in the United States, with more than 200,000 prescriptions.