ABHD12

ABHD12
Identifiers
Aliases	ABHD12, ABHD12A, BEM46L2, C20orf22, PHARC, dJ965G21.2, abhydrolase domain containing 12, habhydrolase domain containing 12, lysophospholipase
External IDs	OMIM: 613599; MGI: 1923442; HomoloGene: 22910; GeneCards: ABHD12; OMA:ABHD12 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	25,390,835 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	150,746,661 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; prefrontal cortex; ; body of pancreas; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens; ; Brodmann area 9;
	Top expressed in
	transitional epithelium of urinary bladder; ; superior frontal gyrus; ; primary visual cortex; ; primary motor cortex; ; seminal vesicula; ; dentate gyrus of hippocampal formation granule cell; ; lateral hypothalamus; ; dorsomedial hypothalamic nucleus; ; pontine nuclei; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; lysophospholipase activity; acylglycerol lipase activity; palmitoyl-(protein) hydrolase activity;
Cellular component	integral component of membrane; plasma membrane; AMPA glutamate receptor complex; membrane; cytoplasm; dendrite cytoplasm;
Biological process	acylglycerol catabolic process; phosphatidylserine catabolic process; adult walking behavior; response to auditory stimulus; monoacylglycerol catabolic process; glycerophospholipid catabolic process; protein depalmitoylation;
	Sources:Amigo / QuickGO
Orthologs
	26090
	76192
	ENSG00000100997
	ENSMUSG00000032046
	Q8N2K0
	Q99LR1
	NM_001042472; NM_015600
	NM_024465; NM_001356549; NM_001356550
	NP_001035937; NP_056415
	NP_077785; NP_001343478; NP_001343479
	Wikidata
View/Edit Human	View/Edit Mouse

alpha/beta-Hydrolase domain containing 12 (ABHD12) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid neurotransmitter 2-arachidonylglycerol (2-AG) in the central nervous system. It is responsible for about 9% of brain 2-AG hydrolysis. Together, ABHD12 along with two other enzymes, monoacylglycerol lipase (MAGL) and ABHD6, control 99% of 2-AG hydrolysis in the brain. ABHD12 also serves as a lysophospholipase and metabolizes lysophosphatidylserine (LPS).