2025 Miami Open – Men's singles

Jakub Menšík defeated Novak Djokovic in the final, 7–6^(7–4), 7–6^(7–4) to win the men's singles tennis title at the 2025 Miami Open. It was his first ATP Tour title. Menšík was the lowest-ranked champion in tournament history at world No. 54, the second unseeded champion at the Miami Open (after Tim Mayotte in 1985), and the fourth player (after Roberto Carretero, Chris Woodruff and Albert Portas) to win a Masters 1000 event as their first tour-level title. The age gap between Djokovic and Menšík (18 years and 102 days) was the largest between two Masters finalists, surpassing the previous record from the 2005 Canadian Open between Rafael Nadal and Andre Agassi.

Jannik Sinner was the reigning champion, but could not defend his title due to a three-month suspension for having tested positive for anabolic steroids during and after the 2024 Indian Wells Open.

With his third-round victory, Djokovic claimed his 411th career main-draw match win at the Masters 1000 level, surpassing Nadal's record. Aged 37 years and 10 months old, Djokovic was the oldest semifinalist and finalist in Masters 1000 history, overtaking Roger Federer's feats from the 2019 Miami Open.

Coleman Wong became the first player from Hong Kong to win a Masters 1000 main draw match and to reach the third round.