ZNF423

ZNF423
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MDG
Identifiers
Aliases	ZNF423, Ebfaz, JBTS19, NPHP14, OAZ, Roaz, ZFP423, Zfp104, hOAZ, zinc finger protein 423
External IDs	OMIM: 604557; MGI: 1891217; HomoloGene: 9010; GeneCards: ZNF423; OMA:ZNF423 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	49,857,919 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	88,686,223 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; cartilage tissue; ; tail of epididymis; ; ganglionic eminence; ; skin of hip; ; Skeletal muscle tissue of rectus abdominis; ; optic nerve; ; vastus lateralis muscle; ; buccal mucosa cell; ; caput epididymis;
	Top expressed in
	tail of embryo; ; genital tubercle; ; medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; zygote; ; lateral septal nucleus; ; lateral geniculate nucleus; ; vestibular sensory epithelium; ; secondary oocyte; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nucleus; nucleoplasm;
Biological process	Notch signaling pathway; positive regulation of transcription, DNA-templated; multicellular organism development; cell differentiation; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; nervous system development; positive regulation of BMP signaling pathway; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23090
	94187
	ENSG00000102935
	ENSMUSG00000045333
	Q2M1K9
	Q80TS5
	NM_001271620; NM_015069; NM_001330533; NM_001379286
	NM_033327; NM_001310520
	NP_001258549; NP_001317462; NP_055884; NP_001366215
	NP_001297449; NP_201584
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mice lacking the homologous gene Zfp423 have defects in midline brain development, especially in the cerebellum, as well as defects in olfactory development, and adipogenesis. Patients with mutations in ZNF423 have been reported in Joubert Syndrome and nephronophthisis.