ZEB2

ZEB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DA7
Identifiers
Aliases	ZEB2, HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B, zinc finger E-box binding homeobox 2
External IDs	OMIM: 605802; MGI: 1344407; HomoloGene: 8868; GeneCards: ZEB2; OMA:ZEB2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	144,521,057 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	45,007,407 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; monocyte; ; C1 segment; ; Achilles tendon; ; corpus callosum; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; epithelium of colon; ; granulocyte; ; Amygdala;
	Top expressed in
	Rostral migratory stream; ; stroma of bone marrow; ; umbilical cord; ; human fetus; ; dentate gyrus; ; iris; ; dentate gyrus of hippocampal formation granule cell; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; phosphatase regulator activity; metal ion binding; protein binding; nucleic acid binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleolus; cytosol;
Biological process	regulation of transcription, DNA-templated; nervous system development; transcription, DNA-templated; positive regulation of melanin biosynthetic process; negative regulation of transcription by RNA polymerase II; neural crest cell migration; somitogenesis; neural tube closure; transcription by RNA polymerase II; central nervous system development; corpus callosum morphogenesis; hippocampus development; cell proliferation in forebrain; corticospinal tract morphogenesis; positive regulation of Wnt signaling pathway; positive regulation of JUN kinase activity; positive regulation of melanocyte differentiation; positive regulation of transcription by RNA polymerase II; developmental pigmentation; embryonic morphogenesis; collateral sprouting; positive regulation of axonogenesis; mammillary axonal complex development; melanocyte migration; positive regulation of lens fiber cell differentiation; regulation of melanosome organization;
	Sources:Amigo / QuickGO
Orthologs
	9839
	24136
	ENSG00000169554
	ENSMUSG00000026872
	O60315
	Q9R0G7
	NM_001171653; NM_014795
NM_015753; NM_001289521; NM_001355288; NM_001355289; NM_001355290;
	NM_001355291
	NP_001165124; NP_055610
NP_001276450; NP_056568; NP_001342217; NP_001342218; NP_001342219;
	NP_001342220
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 protein is a transcription factor that plays a role in the transforming growth factor β (TGFβ) signaling pathways that are essential during early fetal development.