Xipamide

Xipamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	contraindication;
Routes of; administration	By mouth
ATC code	C03BA10 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	95%
Protein binding	98%
Metabolism	glucuronide (30%)
Elimination half-life	5.8 to 8.2 hours
Excretion	kidney (1/3) and bile duct (2/3)
Identifiers
	IUPAC name 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide;
CAS Number	14293-44-8 ;
PubChem CID	26618;
IUPHAR/BPS	7900;
ChemSpider	24795 ;
UNII	4S9EY0NUEC;
KEGG	D06341 ;
ChEMBL	ChEMBL517199 ;
CompTox Dashboard (EPA)	DTXSID5023744 ;
ECHA InfoCard	100.034.727
Chemical and physical data
Formula	C15H15ClN2O4S
Molar mass	354.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N;
	InChI InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22) ; Key:MTZBBNMLMNBNJL-UHFFFAOYSA-N ;
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Xipamide (/ˈzɪpəmaɪd/ ^ⓘ) is a sulfonamide diuretic drug marketed by Eli Lilly under the trade names Aquaphor (in Germany) and Aquaphoril (in Austria). It is used for the treatment of oedema and hypertension.

Clinical data


AHFS/Drugs.com	International Drug Names
Pregnancy category	contraindication
Routes of administration	By mouth
ATC code	C03BA10 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	95%
Protein binding	98%
Metabolism	glucuronide (30%)
Elimination half-life	5.8 to 8.2 hours
Excretion	kidney (1/3) and bile duct (2/3)
Identifiers
IUPAC name 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide
CAS Number	14293-44-8^Y
PubChem CID	26618
IUPHAR/BPS	7900
ChemSpider	24795^N
UNII	4S9EY0NUEC
KEGG	D06341^Y
ChEMBL	ChEMBL517199^N
CompTox Dashboard (EPA)	DTXSID5023744
ECHA InfoCard	100.034.727
Chemical and physical data
Formula	C₁₅H₁₅ClN₂O₄S
Molar mass	354.81 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N
InChI InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)^N Key:MTZBBNMLMNBNJL-UHFFFAOYSA-N^N
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