WDR45

WDR45
Identifiers
Aliases	WDR45, NBIA4, NBIA5, WDRX1, WIPI-4, WIPI4, JM5, WD repeat domain 45
External IDs	OMIM: 300526; MGI: 1859606; HomoloGene: 48498; GeneCards: WDR45; OMA:WDR45 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	49,101,170 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,728,206 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastric mucosa; ; granulocyte; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; canal of the cervix; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of stomach;
	Top expressed in
	morula; ; morula; ; left lung lobe; ; granulocyte; ; neural layer of retina; ; right lung lobe; ; right kidney; ; muscle of thigh; ; superior frontal gyrus; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding; protein binding; protein kinase binding; phosphatidylinositol phosphate binding; lipid binding;
Cellular component	cytosol; phagophore assembly site membrane; extrinsic component of membrane; phagophore assembly site; cytoplasm;
Biological process	autophagy; autophagy of mitochondrion; protein lipidation; protein localization to phagophore assembly site; autophagy of nucleus; autophagosome assembly; cellular response to starvation;
	Sources:Amigo / QuickGO
Orthologs
	11152
	54636
	ENSG00000196998
	ENSMUSG00000039382
	Q9Y484
	Q91VM3
	NM_007075; NM_001029896
	NM_001290792; NM_001290794; NM_001290795; NM_172372
	NP_001025067; NP_009006; NP_001025067.1
	NP_001277721; NP_001277723; NP_001277724; NP_758960
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) is a protein that in humans is encoded by the WDR45 gene. Mutations in this gene cause a distinct form of Neurodegeneration with brain iron accumulation (NBIA) called Beta-propeller protein-associated neurodegeneration (BPAN).