VANGL2

VANGL2
Identifiers
Aliases	VANGL2, LPP1, LTAP, STB1, STBM, STBM1, VANGL planar cell polarity protein 2
External IDs	OMIM: 600533; MGI: 2135272; HomoloGene: 62161; GeneCards: VANGL2; OMA:VANGL2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,428,670 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,856,011 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; buccal mucosa cell; ; ventricular zone; ; skin of arm; ; skin of abdomen; ; skin of leg; ; skin of thigh; ; vagina; ; minor salivary glands; ; cerebellar hemisphere;
	Top expressed in
	ventricular zone; ; molar; ; ganglionic eminence; ; tail of embryo; ; neural plate; ; genital tubercle; ; neural groove; ; lip; ; neural fold; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; cell-cell junction; plasma membrane; cell pole; stress fiber; basolateral plasma membrane; apical plasma membrane; COPII-coated ER to Golgi transport vesicle; cell periphery;
Biological process	hair follicle development; dopaminergic neuron axon guidance; cochlea development; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; non-canonical Wnt signaling pathway; regulation of establishment of planar polarity; lateral sprouting involved in lung morphogenesis; inner ear receptor cell stereocilium organization; regulation of actin cytoskeleton organization; somatic stem cell population maintenance; convergent extension involved in axis elongation; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; positive regulation of JUN kinase activity; muscular septum morphogenesis; serotonergic neuron axon guidance; establishment of planar polarity; membranous septum morphogenesis; somatic stem cell division; planar cell polarity pathway involved in heart morphogenesis; heparan sulfate proteoglycan biosynthetic process; wound healing; glomerulus development; establishment of body hair planar orientation; planar cell polarity pathway involved in axis elongation; establishment of planar polarity involved in neural tube closure; planar cell polarity pathway involved in neural tube closure; multicellular organism development; heart looping; Wnt signaling pathway, planar cell polarity pathway; regulation of Wnt signaling pathway; neural tube closure; inner ear receptor cell development; cochlea morphogenesis; apical protein localization; Rho protein signal transduction; establishment or maintenance of epithelial cell apical/basal polarity; kidney morphogenesis; cell migration involved in kidney development; post-anal tail morphogenesis; convergent extension involved in neural plate elongation; convergent extension involved in organogenesis; anterior/posterior pattern specification; digestive tract morphogenesis; planar cell polarity pathway involved in axon guidance; non-motile cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	57216
	93840
	ENSG00000162738
	ENSMUSG00000026556
	Q9ULK5
	Q91ZD4
	NM_020335
	NM_033509
	NP_065068
	NP_277044
	Wikidata
View/Edit Human	View/Edit Mouse

VANGL planar cell polarity protein 2 is a protein that in humans is encoded by the VANGL2 gene.