UQCRQ

UQCRQ
Identifiers
Aliases	UQCRQ, MC3DN4, QCR8, QP-C, QPC, UQCR7, ubiquinol-cytochrome c reductase complex III subunit VII
External IDs	OMIM: 612080; MGI: 107807; HomoloGene: 40942; GeneCards: UQCRQ; OMA:UQCRQ - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,868,847 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,321,658 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; body of tongue; ; left ventricle; ; renal medulla; ; mucosa of transverse colon; ; vena cava; ; lateral nuclear group of thalamus; ; mucosa of pharynx; ; right auricle of heart; ; gastrocnemius muscle;
	Top expressed in
	interventricular septum; ; choroid plexus of fourth ventricle; ; right kidney; ; plantaris muscle; ; muscle of thigh; ; Ileal epithelium; ; extensor digitorum longus muscle; ; cardiac muscle tissue of left ventricle; ; soleus muscle; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquinol-cytochrome-c reductase activity;
Cellular component	mitochondrial inner membrane; respirasome; mitochondrion; membrane; mitochondrial respiratory chain complex III;
Biological process	pons development; pyramidal neuron development; hippocampus development; cerebellar Purkinje cell layer development; midbrain development; thalamus development; hypothalamus development; subthalamus development; mitochondrial electron transport, ubiquinol to cytochrome c;
	Sources:Amigo / QuickGO
Orthologs
	27089
	22272
	ENSG00000164405
	ENSMUSG00000044894
	O14949
	Q9CQ69
	NM_014402
	NM_025352; NM_001326614
	NP_055217
	NP_001313543; NP_079628
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa is a protein that in humans is encoded by the UQCRQ gene. This ubiqinone-binding protein is a subunit of mitochondrial Complex III in the electron transport chain. A mutation in the UQCRQ gene has been shown to cause severe neurological disorders. Infection by Trypanosoma cruzi can cause oxidative modification of this protein in cardiac muscle tissue.