UGT1A10

UGT1A10
Identifiers
Aliases	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP glucuronosyltransferase family 1 member A10, UGT1-01, UGT-1A, hUG-BR1, UGT1, UGT1A, UGT1.1, GNT1, UGT1A1
External IDs	OMIM: 606435; MGI: 3576092; HomoloGene: 133281; GeneCards: UGT1A10; OMA:UGT1A10 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; rectum; ; gallbladder; ; olfactory zone of nasal mucosa; ; appendix; ; gastric mucosa; ; epithelium of colon; ; body of stomach; ; islet of Langerhans;
	Top expressed in
	hepatobiliary system; ; liver; ; duodenum; ; embryo; ; colon; ; renal cortex; ; proximal tubule; ; stomach; ; human kidney; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; protein heterodimerization activity; enzyme binding; protein kinase C binding; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	negative regulation of cellular glucuronidation; xenobiotic glucuronidation; flavone metabolic process; metabolism; negative regulation of glucuronosyltransferase activity; negative regulation of fatty acid metabolic process; cellular glucuronidation; flavonoid glucuronidation;
	Sources:Amigo / QuickGO
Orthologs
	54575
	394434
	ENSG00000242515
	ENSMUSG00000090175
	Q9HAW8
	Q62452
	NM_019075
	NM_201644
	NP_061948
	NP_964006
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.