Ubiquitin carboxy-terminal hydrolase L1

Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1)
Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1)
	Neurons from rat brain tissue stained green with antibody to ubiquitin C-terminal hydrolase L1 (UCH-L1) which highlights the cell body strongly and the cell processes more weakly. Astrocytes are stained in red with antibody to the GFAP protein found in cytoplasmic filaments. Nuclei of all cell types are stained blue with a DNA binding dye. Antibodies, cell preparation and image generated by EnCor Biotechnology Inc.
	Anatomical terms of microanatomy

UCHL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JKJ, 2ETL, 2LEN, 3IFW, 3IRT, 3KVF, 3KW5, 4DM9
Identifiers
Aliases	UCHL1, HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1, HEL-S-53, ubiquitin C-terminal hydrolase L1, SPG79, UCHL-1
External IDs	OMIM: 191342; MGI: 103149; HomoloGene: 37894; GeneCards: UCHL1; OMA:UCHL1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	41,268,455 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	66,844,577 bp
RNA expression pattern
	Top expressed in
	Pons; ; right frontal lobe; ; lateral nuclear group of thalamus; ; spinal ganglia; ; prefrontal cortex; ; pars compacta; ; superior vestibular nucleus; ; dorsolateral prefrontal cortex; ; Hypothalamus; ; nucleus accumbens;
	Top expressed in
	superior cervical ganglion; ; medial dorsal nucleus; ; superior frontal gyrus; ; transitional epithelium of urinary bladder; ; medial vestibular nucleus; ; ventromedial nucleus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; dorsomedial hypothalamic nucleus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; peptidase activity; ligase activity; ubiquitin binding; protein binding; alpha-2A adrenergic receptor binding; omega peptidase activity; cysteine-type endopeptidase activity; hydrolase activity; ubiquitin protein ligase binding; thiol-dependent deubiquitinase;
Cellular component	cytoplasm; membrane; endoplasmic reticulum membrane; myelin sheath; plasma membrane; intracellular anatomical structure; nucleoplasm; axon; soma; endoplasmic reticulum; neuron projection terminus; axon cytoplasm; cytosol;
Biological process	axon target recognition; eating behavior; axonogenesis; ubiquitin-dependent protein catabolic process; proteolysis; axonal transport of mitochondrion; response to ischemia; neuromuscular process; negative regulation of MAP kinase activity; sensory perception of pain; cell population proliferation; regulation of macroautophagy; adult walking behavior; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	7345
	22223
	ENSG00000154277
	ENSMUSG00000029223
	P09936
	Q9R0P9
	NM_004181
	NM_011670
	NP_004172
	NP_035800
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15, ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme.