UBE3A

UBE3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GIZ, 1C4Z, 1D5F, 1EQX, 2KR1
Identifiers
Aliases	UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A, ubiquitin protein ligase E3A, PIX1
External IDs	OMIM: 601623; MGI: 105098; HomoloGene: 7988; GeneCards: UBE3A; OMA:UBE3A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	25,439,051 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	59,311,536 bp
RNA expression pattern
	Top expressed in
	sperm; ; Skeletal muscle tissue of rectus abdominis; ; Achilles tendon; ; Skeletal muscle tissue of biceps brachii; ; mucosa of paranasal sinus; ; nipple; ; Epithelium of choroid plexus; ; vastus lateralis muscle; ; pylorus; ; cardia;
	Top expressed in
	Rostral migratory stream; ; vas deferens; ; pineal gland; ; ventromedial nucleus; ; medial ganglionic eminence; ; arcuate nucleus; ; efferent ductule; ; median eminence; ; paraventricular nucleus of hypothalamus; ; lateral septal nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; transcription coactivator activity; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	cytosol; proteasome complex; nucleus; cytoplasm;
Biological process	ubiquitin-dependent protein catabolic process; prostate gland growth; rhythmic process; proteolysis; positive regulation of phosphatidylinositol 3-kinase signaling; protein K48-linked ubiquitination; viral process; brain development; regulation of ubiquitin-dependent protein catabolic process; ovarian follicle development; sperm entry; protein ubiquitination; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; protein autoubiquitination; regulation of circadian rhythm; androgen receptor signaling pathway; response to progesterone; progesterone receptor signaling pathway; protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; response to cocaine; response to hydrogen peroxide; negative regulation of dendritic spine morphogenesis; cellular response to brain-derived neurotrophic factor stimulus;
	Sources:Amigo / QuickGO
Orthologs
	7337
	22215
	ENSG00000114062
	ENSMUSG00000025326
	Q05086
	O08759
NM_000462; NM_130838; NM_130839; NM_001354505; NM_001354506;
	NM_001354509; NM_001354512; NM_001354523; NM_001354526; NM_001354540; NM_001354541; NM_001354543; NM_001354545; NM_001354547; NM_001354549; NM_001354550; NM_001354507; NM_001354508; NM_001354511; NM_001354513; NM_001354538; NM_001354539; NM_001354542; NM_001354544; NM_001354546; NM_001354548; NM_001354551; NM_001374461
	NM_001033962; NM_011668; NM_173010
NP_000453; NP_570853; NP_570854; NP_001341434; NP_001341435;
	NP_001341438; NP_001341441; NP_001341452; NP_001341455; NP_001341469; NP_001341470; NP_001341472; NP_001341474; NP_001341476; NP_001341478; NP_001341479; NP_001341436; NP_001341437; NP_001341440; NP_001341442; NP_001341467; NP_001341468; NP_001341471; NP_001341473; NP_001341475; NP_001341477; NP_001341480; NP_001361390
NP_001029134; NP_035798; NP_001380595; NP_001380597; NP_001380598;
	NP_001380599; NP_001380600; NP_001380601; NP_766598; NP_001380902
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting proteins for degradation within cells.