UBE2H

UBE2H
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z5D
Identifiers
Aliases	UBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H
External IDs	OMIM: 601082; MGI: 104632; HomoloGene: 103894; GeneCards: UBE2H; OMA:UBE2H - orthologs
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 7 (human)
End	129,952,960 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,304,538 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right adrenal cortex; ; epithelium of colon; ; saphenous vein; ; internal globus pallidus; ; Skeletal muscle tissue of biceps brachii; ; amniotic fluid; ; islet of Langerhans; ; left adrenal gland; ; caput epididymis;
	Top expressed in
	blood; ; retinal pigment epithelium; ; Rostral migratory stream; ; tibiofemoral joint; ; substantia nigra; ; medullary collecting duct; ; ascending aorta; ; ciliary body; ; condyle; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein binding; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	protein K48-linked ubiquitination; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K11-linked ubiquitination; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	7328
	22214
	ENSG00000186591
	ENSMUSG00000039159
	P62256
	P62257
	NM_001202498; NM_003344; NM_182697
	NM_001169576; NM_001169577; NM_009459
	NP_001189427; NP_003335; NP_874356; NP_003335.1
	NP_001163047; NP_001163048; NP_033485
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.