UBE2B

UBE2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JAS, 2Y4W, 2YB6, 2YBF
Identifiers
Aliases	UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin conjugating enzyme E2 B
External IDs	OMIM: 179095; MGI: 102944; HomoloGene: 101298; GeneCards: UBE2B; OMA:UBE2B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	134,392,108 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	51,891,589 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; right lung; ; right auricle of heart; ; biceps brachii; ; body of pancreas; ; Descending thoracic aorta; ; anterior pituitary; ; ganglionic eminence;
	Top expressed in
	intercostal muscle; ; medial head of gastrocnemius muscle; ; muscle of thigh; ; quadriceps femoris muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; atrioventricular valve; ; arcuate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; protein binding; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding;
Cellular component	cytoplasm; membrane; plasma membrane; replication fork; HULC complex; nucleoplasm; XY body; chromatin; nucleus;
Biological process	chiasma assembly; histone H2A ubiquitination; negative regulation of cAMP-mediated signaling; postreplication repair; ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; meiotic telomere clustering; positive regulation of reciprocal meiotic recombination; protein stabilization; protein polyubiquitination; negative regulation of apoptotic process; in utero embryonic development; protein monoubiquitination; sperm axoneme assembly; cellular response to DNA damage stimulus; protein K11-linked ubiquitination; histone lysine demethylation; protein K48-linked ubiquitination; regulation of histone modification; spermatogenesis; canonical Wnt signaling pathway; synaptonemal complex organization; response to UV; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; DNA repair; protein ubiquitination; positive regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7320
	22210
	ENSG00000119048
	ENSMUSG00000020390
	P63146
	P63147
	NM_003337
	NM_009458; NM_001362685; NM_001362686
	NP_003328
	NP_033484; NP_001349614; NP_001349615
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.