UBAP1

UBAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGN, 4AE4
Identifiers
Aliases	UBAP1, NAG20, UAP, UBAP, UBAP-1, ubiquitin associated protein 1, SPG80
External IDs	OMIM: 609787; MGI: 2149543; HomoloGene: 9554; GeneCards: UBAP1; OMA:UBAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	34,252,523 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,390,525 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; muscle of thigh; ; islet of Langerhans; ; ventricular zone; ; ectocervix; ; blood; ; tibial arteries;
	Top expressed in
	granulocyte; ; ventricular zone; ; muscle of thigh; ; blood; ; tail of embryo; ; duodenum; ; right kidney; ; esophagus; ; neural layer of retina; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin binding; protein binding;
Cellular component	cytoplasm; cytosol; endosome; plasma membrane; Golgi apparatus; ESCRT I complex; endosome membrane; host cell;
Biological process	protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; endosomal transport; viral life cycle; intracellular transport of virus;
	Sources:Amigo / QuickGO
Orthologs
	51271
	67123
	ENSG00000165006
	ENSMUSG00000028437
	Q9NZ09
	Q8BH48
	NM_001171201; NM_001171202; NM_001171203; NM_001171204; NM_016525
	NM_001290454; NM_023305; NM_001355508; NM_001355509
	NP_001164672; NP_001164673; NP_001164674; NP_001164675; NP_057609
	NP_001277383; NP_075794; NP_001342437; NP_001342438
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.

This gene is a member of the ubiquitin-associated domain (UBA) family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin-binding domain consisting of a compact three-helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Truncating Mutations in UBAP1 Cause Hereditary Spastic Paraplegia.