Outer membrane receptor
| TonB dependent receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of ferric hydroxamate uptake receptor. | |||||||||
| Identifiers | |||||||||
| Symbol | TonB_dep_Rec | ||||||||
| Pfam | PF00593 | ||||||||
| Pfam clan | CL0193 | ||||||||
| InterPro | IPR000531 | ||||||||
| PROSITE | PDOC00354 | ||||||||
| SCOP2 | 2fcp / SCOPe / SUPFAM | ||||||||
| TCDB | 1.B.14 | ||||||||
| OPM superfamily | 33 | ||||||||
| OPM protein | 1qfg | ||||||||
| CDD | cd01347 | ||||||||
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Outer membrane receptors, also known as TonB-dependent receptors, are a family of beta barrel proteins named for their localization in the outer membrane of gram-negative bacteria. TonB complexes sense signals from the outside of bacterial cells and transmit them into the cytoplasm, leading to transcriptional activation of target genes. TonB-dependent receptors in gram-negative bacteria are associated with the uptake and transport of large substrates such as iron siderophore complexes and vitamin B12.