TYROBP

TYROBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L34, 2L35, 4WO1, 4WOL
Identifiers
Aliases	TYROBP, DAP12, KARAP, PLOSL, TYRO protein tyrosine kinase binding protein, PLOSL1, transmembrane immune signaling adaptor TYROBP
External IDs	OMIM: 604142; MGI: 1277211; HomoloGene: 7986; GeneCards: TYROBP; OMA:TYROBP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,908,295 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,117,010 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; spleen; ; right lung; ; bone marrow; ; periodontal fiber; ; upper lobe of left lung; ; bone marrow cells; ; gallbladder;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; mesenteric lymph nodes; ; spleen; ; calvaria; ; stroma of bone marrow; ; right lung lobe; ; blood; ; internal carotid artery; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; identical protein binding; metal ion binding;
Cellular component	integral component of membrane; cell surface; plasma membrane; integral component of plasma membrane; membrane; secretory granule membrane;
Biological process	integrin-mediated signaling pathway; macrophage activation involved in immune response; cellular defense response; neutrophil activation involved in immune response; intracellular signal transduction; innate immune response; regulation of osteoclast development; signal transduction; regulation of immune response; neutrophil degranulation; osteoclast differentiation; myeloid leukocyte activation; positive regulation of natural killer cell activation; positive regulation of macrophage fusion; protein stabilization; positive regulation of microglial cell mediated cytotoxicity; positive regulation of protein localization to cell surface; positive regulation of osteoclast development; microglial cell activation involved in immune response; positive regulation of gene expression; actin cytoskeleton organization; negative regulation of B cell proliferation; forebrain development; negative regulation of transforming growth factor beta1 production; positive regulation of superoxide anion generation; response to axon injury; apoptotic signaling pathway; positive regulation of hippocampal neuron apoptotic process; negative regulation of long-term synaptic potentiation; positive regulation of neuron death; positive regulation of receptor localization to synapse; apoptotic cell clearance; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	7305
	22177
	ENSG00000011600
	ENSMUSG00000030579
	O43914
	O54885
	NM_001173514; NM_001173515; NM_003332; NM_198125
	NM_011662
	NP_001166985; NP_001166986; NP_003323; NP_937758
	NP_035792
	Wikidata
View/Edit Human	View/Edit Mouse

TYRO protein tyrosine kinase-binding protein is an adapter protein that in humans is encoded by the TYROBP gene.