TTF2

TTF2
Identifiers
Aliases	TTF2, HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2, F2
External IDs	OMIM: 604718; MGI: 1921294; HomoloGene: 37826; GeneCards: TTF2; OMA:TTF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,107,453 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,969,663 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; epithelium of colon; ; Achilles tendon; ; bone marrow cells; ; gonad; ; rectum; ; epithelium of nasopharynx; ; appendix; ; mucosa of esophagus; ; testicle;
	Top expressed in
	hand; ; primitive streak; ; medullary collecting duct; ; epiblast; ; otic vesicle; ; mandibular prominence; ; maxillary prominence; ; hair follicle; ; endothelial cell of lymphatic vessel; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; zinc ion binding; protein binding; ATP binding; helicase activity; hydrolase activity;
Cellular component	spliceosomal complex; transcription elongation factor complex; nucleus; cytoplasm; cytosol;
Biological process	DNA-templated transcription, termination; termination of RNA polymerase II transcription; mRNA processing; regulation of transcription, DNA-templated; RNA splicing; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	8458
	74044
	ENSG00000116830
	ENSMUSG00000033222
	Q9UNY4
	Q5NC05
	NM_003594
	NM_001013026
	NP_003585
	NP_001013044
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.