TSPAN4

TSPAN4
Identifiers
Aliases	TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs	OMIM: 602644; MGI: 1928097; HomoloGene: 2453; GeneCards: TSPAN4; OMA:TSPAN4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	867,116 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,073,340 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lung; ; left uterine tube; ; right ovary; ; canal of the cervix; ; left ovary; ; body of uterus; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; tibial nerve;
	Top expressed in
	stroma of bone marrow; ; decidua; ; calvaria; ; gastrula; ; endothelial cell of lymphatic vessel; ; internal carotid artery; ; external carotid artery; ; right kidney; ; adrenal gland; ; choroid plexus of fourth ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	antigen binding; integrin binding; protein binding;
Cellular component	integral component of membrane; vesicle; plasma membrane; integral component of plasma membrane; membrane; focal adhesion;
Biological process	cell surface receptor signaling pathway; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7106
	64540
	ENSG00000214063
	ENSMUSG00000025511
	O14817
	Q9DCK3
NM_001025234; NM_001025235; NM_001025236; NM_001025237; NM_001025238;
	NM_001025239; NM_003271
	NM_001252588; NM_053082
NP_001020405; NP_001020406; NP_001020407; NP_001020408; NP_001020409;
	NP_001020410; NP_003262
NP_001239517; NP_444312; NP_001390284; NP_001390285; NP_001390286;
	NP_001390287
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.