TRMU

TRMU
Identifiers
Aliases	TRMU, MTO2, MTU1, TRMT, TRMT1, TRNT1, LCAL3, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase, tRNA mitochondrial 2-thiouridylase
External IDs	OMIM: 610230; MGI: 1919276; HomoloGene: 5589; GeneCards: TRMU; OMA:TRMU - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	46,357,340 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,781,595 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; right auricle of heart; ; right lobe of thyroid gland; ; body of pancreas; ; ventricular zone; ; left ovary; ; right ovary;
	Top expressed in
	neural layer of retina; ; right kidney; ; interventricular septum; ; proximal tubule; ; otolith organ; ; neural tube; ; lens; ; utricle; ; ventricular zone; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding; transferase activity; tRNA binding; nucleotide binding; sulfurtransferase activity; ATP binding; methyltransferase activity;
Cellular component	mitochondrion; nucleoplasm;
Biological process	tRNA wobble position uridine thiolation; mitochondrial tRNA thio-modification; tRNA processing; methylation;
	Sources:Amigo / QuickGO
Orthologs
	55687
	72026
	ENSG00000100416
	ENSMUSG00000022386
	O75648; Q2PPL5
	Q9DAT5
NM_001008569; NM_001008571; NM_001282782; NM_001282783; NM_001282784;
	NM_001282785; NM_018006
	NM_028063
NP_001269711; NP_001269712; NP_001269713; NP_001269714; NP_060476;
	NP_001269711.1
	NP_082339
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.

This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.