TREM2

TREM2
Identifiers
Aliases	TREM2, TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL2
External IDs	OMIM: 605086; MGI: 1913150; HomoloGene: 10352; GeneCards: TREM2; OMA:TREM2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,163,186 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	48,661,175 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; amniotic fluid; ; inferior ganglion of vagus nerve; ; substantia nigra; ; optic nerve; ; right coronary artery; ; gallbladder; ; left adrenal gland; ; subthalamic nucleus; ; upper lobe of left lung;
	Top expressed in
	white adipose tissue; ; striatum of neuraxis; ; hippocampus proper; ; urinary bladder; ; dentate gyrus of hippocampal formation granule cell; ; corpus callosum; ; superior frontal gyrus; ; mesenchyme; ; ovary; ; olfactory bulb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; lipopolysaccharide binding; lipoteichoic acid binding; peptidoglycan binding; phospholipid binding; signaling receptor activity; amyloid-beta binding; high-density lipoprotein particle binding; lipid binding; low-density lipoprotein particle binding; apolipoprotein binding; apolipoprotein A-I binding; very-low-density lipoprotein particle binding; protein-containing complex binding; lipoprotein particle binding; protein tyrosine kinase binding; protein binding;
Cellular component	integral component of membrane; membrane; extracellular region; plasma membrane; integral component of plasma membrane; intrinsic component of plasma membrane;
Biological process	dendritic cell differentiation; positive regulation of CD40 signaling pathway; positive regulation of calcium-mediated signaling; positive regulation of C-C chemokine receptor CCR7 signaling pathway; phagocytosis, engulfment; detection of peptidoglycan; humoral immune response; cellular response to lipoteichoic acid; positive regulation of protein localization to plasma membrane; regulation of immune response; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipoteichoic acid; innate immune response; detection of lipopolysaccharide; cellular response to peptidoglycan; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of ERK1 and ERK2 cascade; signal transduction; osteoclast differentiation; positive regulation of macrophage fusion; positive regulation of amyloid-beta clearance; positive regulation of protein phosphorylation; regulation of gene expression; negative regulation of autophagy; positive regulation of gene expression; positive regulation of mitochondrion organization; regulation of TOR signaling; positive regulation of TOR signaling; regulation of interleukin-6 production; regulation of peptidyl-tyrosine phosphorylation; positive regulation of chemotaxis; regulation of resting membrane potential; positive regulation of astrocyte activation; regulation of macrophage inflammatory protein 1 alpha production; import into cell; regulation of plasma membrane bounded cell projection organization; positive regulation of proteasomal protein catabolic process; positive regulation of inward rectifier potassium channel activity; regulation of intracellular signal transduction; positive regulation of microglial cell activation; negative regulation of autophagic cell death; positive regulation of microglial cell migration; cellular response to amyloid-beta; positive regulation of CAMKK-AMPK signaling cascade; positive regulation of ATP biosynthetic process; apoptotic cell clearance; positive regulation of protein secretion; microglial cell activation; response to ischemia; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; positive regulation of interleukin-10 production; negative regulation of apoptotic process; positive regulation of osteoclast differentiation; positive regulation of NIK/NF-kappaB signaling; microglial cell activation involved in immune response; defense response to bacterium; regulation of innate immune response; positive regulation of phagocytosis, engulfment; microglial cell proliferation; amyloid-beta clearance; complement-mediated synapse pruning; neuroinflammatory response; positive regulation of neuroinflammatory response; positive regulation of engulfment of apoptotic cell;
	Sources:Amigo / QuickGO
Orthologs
	54209
	83433
	ENSG00000095970
	ENSMUSG00000023992
	Q9NZC2
	Q99NH8
	NM_001271821; NM_018965
	NM_001272078; NM_031254
	NP_001258750; NP_061838
	NP_001259007; NP_112544
	Wikidata
View/Edit Human	View/Edit Mouse

Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. In the liver, TREM2 is expressed by several cell types, including macrophages, that respond to injury. In the intestine, TREM2 is expressed by myeloid-derived dendritic cells and macrophage. TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. It might therefore be a good therapeutic target.