TRAF3

TRAF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FLK, 1FLL, 1KZZ, 1L0A, 1RF3, 1ZMS, 2ECY, 2GKW
Identifiers
Aliases	TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118
External IDs	OMIM: 601896; MGI: 108041; HomoloGene: 7981; GeneCards: TRAF3; OMA:TRAF3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	102,911,500 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,233,587 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; monocyte; ; Brodmann area 46; ; appendix; ; middle temporal gyrus; ; granulocyte; ; postcentral gyrus; ; lymph node; ; testicle; ; tibia;
	Top expressed in
	CA3 field; ; vestibular sensory epithelium; ; ventral tegmental area; ; Epithelium of choroid plexus; ; central gray substance of midbrain; ; entorhinal cortex; ; subiculum; ; dorsomedial hypothalamic nucleus; ; lacrimal gland; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; signal transducer activity; metal ion binding; protein binding; thioesterase binding; protein phosphatase binding; protein kinase binding; ubiquitin protein ligase binding; transferase activity; ubiquitin-protein transferase activity; tumor necrosis factor receptor binding;
Cellular component	cytoplasm; cytosol; endosome; mitochondrion; cytoplasmic side of plasma membrane; CD40 receptor complex; protein-containing complex;
Biological process	regulation of apoptotic process; Toll signaling pathway; immune system process; TRIF-dependent toll-like receptor signaling pathway; protein ubiquitination; negative regulation of NF-kappaB transcription factor activity; regulation of proteolysis; apoptotic process; toll-like receptor signaling pathway; regulation of cytokine production; signal transduction; regulation of interferon-beta production; innate immune response; tumor necrosis factor-mediated signaling pathway; regulation of defense response to virus; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	7187
	22031
	ENSG00000131323
	ENSMUSG00000021277
	Q13114
	Q60803
NM_001199427; NM_003300; NM_145725; NM_145726; NM_001385142;
	NM_001385143
	NM_001048206; NM_001286122; NM_011632; NM_001364364
	NP_001186356; NP_003291; NP_663777; NP_663778
	NP_001273051; NP_035762; NP_001351293
	Wikidata
View/Edit Human	View/Edit Mouse

TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene.