Translationally controlled tumor protein

TPT1-AS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YZ1, 3EBM, 4Z9V, 2HR9
Identifiers
Aliases	TPT1-AS1, HRF, TCTP, p02, p23, tumor protein, translationally-controlled 1, TPT1 antisense RNA 1
External IDs	OMIM: 600763; MGI: 104890; HomoloGene: 55730; GeneCards: TPT1-AS1; OMA:TPT1-AS1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	76,085,965 bp
RNA expression pattern
	n/a
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; epiblast; ; thymus; ; zone of skin; ; spleen; ; esophagus; ; lip; ; uterus; ; quadriceps femoris muscle;
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; microtubule binding; RNA binding;
Cellular component	cytoplasm; multivesicular body; tubulin complex; extracellular exosome; nucleus; extracellular space; cytosol; spindle pole; cytoplasmic microtubule;
Biological process	regulation of apoptotic process; response to virus; cellular calcium ion homeostasis; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; calcium ion transport; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	100190939
	22070
	ENSG00000170919
	ENSMUSG00000060126
	P13693
	P63028
	n/a
	NM_009429
	NP_001273201; NP_001273202; NP_003286
	NP_033455
	Wikidata
View/Edit Human	View/Edit Mouse

Translationally controlled tumor protein (TCTP) is a protein that in humans is encoded by the TPT1 gene. TPT1 is mapped to 13q12-q14 on chromosome 13. The human gene contains five introns and six exons, TPT1 contains a promoter with a canonical TATA-box and several promoter elements, which are well-conserved in mammals. The assay with reporter gene exhibits a strong promoter activity comparable to viral promoters.

TCTP protein is also known as p23, Fortilin, and histamine-releasing factor.

TCTP is a multifunctional and highly conserved protein that existed ubiquitously in different eukaryote species and distributed widely in various tissues and cell types.

TCTP in the human is a growth-related, calcium-binding protein.