TPSAB1

TPSAB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A0L, 2BM2, 2FPZ, 2FS8, 2FS9, 2FWW, 2FXR, 2GDD, 2ZA5, 3V7T,%%s1LTO, 2F9N, 2F9O, 2F9P, 2ZEB, 2ZEC, 4A6L, 4MPU, 4MPV, 4MPW, 4MPX, 4MQA, 5F03
Identifiers
Aliases	TPSAB1, TPS1, TPS2, TPSB1, tryptase alpha/beta 1, TPSB2, Tryptase-2
External IDs	OMIM: 191080; MGI: 96942; HomoloGene: 55729; GeneCards: TPSAB1; OMA:TPSAB1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,242,554 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,588,072 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; fundus; ; duodenum; ; right lung; ; upper lobe of left lung; ; mucosa of transverse colon; ; gastric mucosa; ; right coronary artery; ; skin of leg; ; body of stomach;
	Top expressed in
	dermis; ; lip; ; Ileal epithelium; ; lactiferous gland; ; foreskin; ; muscle of thigh; ; extraocular muscle; ; skin of back; ; ankle; ; gastric mucosa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; serine-type endopeptidase activity; identical protein binding;
Cellular component	extracellular region; extracellular matrix; extracellular space; collagen-containing extracellular matrix;
Biological process	proteolysis; defense response; extracellular matrix disassembly;
	Sources:Amigo / QuickGO
Orthologs
	7177
	17229
	ENSG00000172236
	ENSMUSG00000033825
	P20231; Q15661
	P21845
	NM_003294
	NM_010781
	NP_077078; NP_003285
	NP_034911
	Wikidata
View/Edit Human	View/Edit Mouse

Tryptase alpha-1 and tryptase beta-1 are enzymes that in humans are encoded by the same TPSAB1 gene. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate.