TPPP

TPPP
Identifiers
Aliases	TPPP, TPPP/p25, TPPP1, p24, p25, p25alpha, tubulin polymerization promoting protein
External IDs	OMIM: 608773; MGI: 1920198; HomoloGene: 21389; GeneCards: TPPP; OMA:TPPP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	693,352 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,183,872 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; internal globus pallidus; ; entorhinal cortex; ; inferior ganglion of vagus nerve; ; superior frontal gyrus; ; ventral tegmental area; ; superior vestibular nucleus; ; subthalamic nucleus;
	Top expressed in
	primary motor cortex; ; ventral tegmental area; ; cingulate gyrus; ; piriform cortex; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; superior colliculus; ; lateral hypothalamus; ; subiculum; ; suprachiasmatic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; protein binding; tubulin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; myelin sheath; microtubule; cytoskeleton; nucleus; mitochondrion; cytosol; microtubule bundle;
Biological process	microtubule polymerization; positive regulation of protein-containing complex assembly; positive regulation of protein polymerization; microtubule bundle formation;
	Sources:Amigo / QuickGO
Orthologs
	11076
	72948
	ENSG00000171368
	ENSMUSG00000021573
	O94811
	Q7TQD2
	NM_007030
	NM_182839
	NP_008961
	NP_878259
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.

This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.

This has also been linked to Parkinson's and Alzheimer's Disease