Tripeptidyl peptidase II

TPP2
Identifiers
Aliases	TPP2, TPP-2, TPPII, Tripeptidyl peptidase II, tripeptidyl peptidase 2, TPP-II, IMD78
External IDs	OMIM: 190470; MGI: 102724; HomoloGene: 2471; GeneCards: TPP2; OMA:TPP2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	102,679,958 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	44,042,160 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; Achilles tendon; ; epithelium of colon; ; monocyte; ; rectum; ; testicle; ; muscle of thigh; ; right uterine tube;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; tail of embryo; ; esophagus; ; mandibular prominence; ; maxillary prominence; ; atrioventricular valve; ; gastrula; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	tripeptidyl-peptidase activity; peptidase activity; endopeptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; aminopeptidase activity; serine-type endopeptidase activity; identical protein binding;
Cellular component	nucleus; nucleoplasm; cytoplasm; cytosol; nuclear body;
Biological process	protein polyubiquitination; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	7174
	22019
	ENSG00000134900
	ENSMUSG00000041763
	P29144
	Q64514
	NM_003291; NM_001330588; NM_001367947
	NM_009418; NM_001310540
	NP_001317517; NP_003282; NP_001354876
	NP_001297469; NP_033444
	Wikidata
View/Edit Human	View/Edit Mouse

Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene. Among other things it is heavily implicated in MHC (HLA) class-I processing, as it has both endopeptidase and exopeptidase activity.