TPM1

TPM1
Identifiers
Aliases	TPM1, C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA, HEL-S-265, tropomyosin 1 (alpha), tropomyosin 1
External IDs	OMIM: 191010; MGI: 98809; HomoloGene: 121635; GeneCards: TPM1; OMA:TPM1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	63,071,915 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,956,688 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; right ventricle; ; atrium; ; right auricle of heart; ; seminal vesicula; ; apex of heart; ; cardiac muscle tissue of right atrium; ; Skeletal muscle tissue of rectus abdominis; ; saphenous vein; ; muscle layer of sigmoid colon;
	Top expressed in
	ankle; ; aortic valve; ; medial head of gastrocnemius muscle; ; tail of embryo; ; ascending aorta; ; masseter muscle; ; muscle of thigh; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; structural constituent of cytoskeleton; protein binding; actin binding; structural constituent of muscle; identical protein binding; protein homodimerization activity; protein heterodimerization activity; actin filament binding;
Cellular component	cytoplasm; muscle thin filament tropomyosin; sarcomere; stress fiber; ruffle membrane; bleb; cytoskeleton; cytosol; actin filament; actin cytoskeleton; myofibril; filamentous actin;
Biological process	regulation of muscle contraction; muscle contraction; regulation of heart contraction; positive regulation of ATP-dependent activity; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell proliferation; ruffle organization; wound healing; cellular response to reactive oxygen species; negative regulation of cell migration; cytoskeleton organization; regulation of cell shape; muscle filament sliding; sarcomere organization; positive regulation of stress fiber assembly; positive regulation of cell adhesion; actin filament organization; in utero embryonic development; positive regulation of heart rate by epinephrine; ventricular cardiac muscle tissue morphogenesis; cardiac muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	7168
	22003
	ENSG00000140416
	ENSMUSG00000032366
	P09493
	P58771
NM_000366; NM_001018004; NM_001018005; NM_001018006; NM_001018007;
	NM_001018008; NM_001018020; NM_001301244; NM_001301289; NM_001330344; NM_001330346; NM_001330351; NM_001365776; NM_001365777; NM_001365778; NM_001365779; NM_001365780; NM_001365781; NM_001365782
NM_001164248; NM_001164249; NM_001164250; NM_001164251; NM_001164252;
	NM_001164253; NM_001164254; NM_001164255; NM_001164256; NM_024427
NP_000357; NP_001018004; NP_001018005; NP_001018006; NP_001018007;
	NP_001018008; NP_001018020; NP_001288173; NP_001288218; NP_001317273; NP_001317275; NP_001317280; NP_001352705; NP_001352706; NP_001352707; NP_001352708; NP_001352709; NP_001352710; NP_001352711; NP_001018006.1
NP_001157720; NP_001157721; NP_001157722; NP_001157723; NP_001157724;
	NP_001157725; NP_001157726; NP_001157727; NP_001157728; NP_077745
	Wikidata
View/Edit Human	View/Edit Mouse

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells.