TPI1

TPI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IAN, 1WYI, 4POC, 1HTI, 2VOM, 1KLG, 4BR1, 4E41, 4UNK, 2IAM, 1KLU, 2JK2, 4UNL, 4POD, 4ZVJ
Identifiers
Aliases	TPI1, HEL-S-49, TIM, TPI, TPID, triosephosphate isomerase 1
External IDs	OMIM: 190450; MGI: 98797; HomoloGene: 128432; GeneCards: TPI1; OMA:TPI1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,870,948 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,791,259 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; right hemisphere of cerebellum; ; ventricular zone; ; mucosa of transverse colon; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex;
	Top expressed in
	epithelium of small intestine; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; temporal muscle; ; intercostal muscle; ; tibialis anterior muscle; ; skeletal muscle tissue; ; gastrocnemius muscle; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	triose-phosphate isomerase activity; protein binding; catalytic activity; isomerase activity; ubiquitin protein ligase binding; methylglyoxal synthase activity; protein homodimerization activity; lyase activity;
Cellular component	cytosol; extracellular exosome; nucleus; extracellular space; cytoplasm;
Biological process	canonical glycolysis; multicellular organism development; gluconeogenesis; pentose-phosphate shunt; metabolism; glyceraldehyde-3-phosphate metabolic process; glycolytic process; glycerol catabolic process; glyceraldehyde-3-phosphate biosynthetic process; glucose metabolic process; methylglyoxal biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7167
	21991
	ENSG00000111669
	ENSMUSG00000023456
	P60174
	P17751
	NM_001258026; NM_000365; NM_001159287
	NM_009415
	NP_000356; NP_001152759; NP_001244955
	NP_033441
	Wikidata
View/Edit Human	View/Edit Mouse

Triosephosphate isomerase is an enzyme that in humans is encoded by the TPI1 gene.

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.