TP53RK

TP53RK
Identifiers
Aliases	TP53RK, BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2, TP53 regulating kinase, GAMOS4, TPRKB
External IDs	OMIM: 608679; MGI: 1914050; HomoloGene: 6042; GeneCards: TP53RK; OMA:TP53RK - orthologs
EC number	3.6.-.-
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,689,444 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	166,641,425 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; islet of Langerhans; ; bronchial epithelial cell; ; stromal cell of endometrium; ; gonad; ; cartilage tissue; ; olfactory zone of nasal mucosa; ; right adrenal cortex; ; epithelium of nasopharynx;
	Top expressed in
	spermatid; ; female urethra; ; embryo; ; granulocyte; ; embryo; ; lumbar spinal ganglion; ; primitive streak; ; stroma of kidney; ; epiblast; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; p53 binding; protein binding; ATP binding; hydrolase activity; phosphotransferase activity, alcohol group as acceptor; protein serine/threonine kinase activity;
Cellular component	cytosol; membrane; nucleus; nucleoplasm; EKC/KEOPS complex; cytoplasm;
Biological process	protein phosphorylation; phosphorylation; tRNA threonylcarbamoyladenosine metabolic process; tRNA processing; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	112858
	76367
	ENSG00000172315
	ENSMUSG00000042854
	Q96S44
	Q99PW4
	NM_033550
	NM_023815
	NP_291028
	NP_076304.2
	Wikidata
View/Edit Human	View/Edit Mouse

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene. This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

PRPK is part of the KEOPS/EKC complex, which participates in transcription control, telomere regulation and tRNA modification.