TP53BP2

TP53BP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YCS, 2UWQ, 4A63, 4IRV
Identifiers
Aliases	TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
External IDs	OMIM: 602143; MGI: 2138319; HomoloGene: 3959; GeneCards: TP53BP2; OMA:TP53BP2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	223,845,954 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	182,289,997 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; caudate nucleus; ; putamen; ; external globus pallidus; ; nucleus accumbens; ; Amygdala; ; retinal pigment epithelium; ; pars reticulata; ; epithelium of colon;
	Top expressed in
	genital tubercle; ; tail of embryo; ; vestibular membrane of cochlear duct; ; hand; ; superior cervical ganglion; ; glomerulus; ; otolith organ; ; utricle; ; lumbar subsegment of spinal cord; ; human kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; p53 binding; SH3 domain binding; NF-kappaB binding;
Cellular component	perinuclear region of cytoplasm; nucleus; cytoplasm; mitochondrion; nucleoplasm; cytosol; cell junction;
Biological process	cell cycle; negative regulation of cell cycle; positive regulation of execution phase of apoptosis; signal transduction; intrinsic apoptotic signaling pathway by p53 class mediator; apoptotic process; positive regulation of neuron death; regulation of signal transduction by p53 class mediator; regulation of apoptotic process; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7159
	209456
	ENSG00000143514
	ENSMUSG00000026510
	Q13625
	Q8CG79
	NM_001031685; NM_005426
	NM_173378
	NP_001026855; NP_005417
	NP_775554
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.