TP53BP1

TP53BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG
Identifiers
Aliases	TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1
External IDs	OMIM: 605230; MGI: 1351320; HomoloGene: 4137; GeneCards: TP53BP1; OMA:TP53BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	43,510,728 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	121,101,888 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; gonad; ; ventricular zone; ; stromal cell of endometrium; ; Achilles tendon; ; right uterine tube; ; ganglionic eminence; ; middle temporal gyrus; ; sural nerve;
	Top expressed in
	primary oocyte; ; ascending aorta; ; substantia nigra; ; secondary oocyte; ; ciliary body; ; fossa; ; renal corpuscle; ; Rostral migratory stream; ; aortic valve; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coregulator activity; p53 binding; protein binding; ubiquitin modification-dependent histone binding; damaged DNA binding; methylated histone binding; telomeric DNA binding; sequence-specific DNA binding; histone binding;
Cellular component	cytoplasm; nucleoplasm; chromosome; telomere; chromosome, centromeric region; kinetochore; nuclear body; nucleus; replication fork; site of double-strand break; DNA repair complex;
Biological process	regulation of transcription, DNA-templated; cellular response to X-ray; DNA damage checkpoint signaling; positive regulation of DNA-binding transcription factor activity; transcription, DNA-templated; cellular response to DNA damage stimulus; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; DNA repair; protein homooligomerization; double-strand break repair via nonhomologous end joining; positive regulation of isotype switching; negative regulation of double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	7158
	27223
	ENSG00000067369
	ENSMUSG00000043909
	Q12888
	P70399
	NM_001141979; NM_001141980; NM_005657; NM_001355001
	NM_001290830; NM_013735
	NP_001135451; NP_001135452; NP_005648; NP_001341930
	NP_001277759; NP_038763
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.