TOPORS

TOPORS
Identifiers
Aliases	TOPORS, LUN, P53BP3, RP31, TP53BPL, TOP1 binding arginine/serine rich protein, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
External IDs	OMIM: 609507; MGI: 2146189; HomoloGene: 4237; GeneCards: TOPORS; OMA:TOPORS - orthologs
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	40,269,850 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; sperm; ; corpus epididymis; ; caput epididymis; ; trabecular bone; ; jejunal mucosa; ; seminal vesicula; ; oral cavity; ; bone marrow;
	Top expressed in
	primitive streak; ; maxillary prominence; ; mandibular prominence; ; hand; ; medial ganglionic eminence; ; Gonadal ridge; ; endothelial cell of lymphatic vessel; ; left lung lobe; ; dermis; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding; DNA binding; SUMO transferase activity; ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; DNA topoisomerase binding; protein binding; transferase activity;
Cellular component	ciliary basal body; PML body; nuclear speck; spindle pole; ubiquitin ligase complex; gamma-tubulin complex; photoreceptor connecting cilium; midbody; cytoplasmic dynein complex; centriole; nucleus; nucleoplasm;
Biological process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; retina layer formation; ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of apoptotic process; retinal cone cell development; protein monoubiquitination; photoreceptor cell outer segment organization; protein sumoylation; transcription, DNA-templated; cellular response to DNA damage stimulus; positive regulation of transcription, DNA-templated; protein K48-linked ubiquitination; regulation of cell population proliferation; positive regulation of ubiquitin-protein transferase activity; retinal rod cell development; intrinsic apoptotic signaling pathway in response to DNA damage; protein localization to nucleus; maintenance of protein location in nucleus; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10210
	106021
	n/a
	ENSMUSG00000036822
	Q9NS56
	Q80Z37
	NM_005802; NM_001195622
	NM_134097
	NP_001182551; NP_005793
	NP_598858
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase Topors is an enzyme that in humans is encoded by the TOPORS gene.