TOB2

TOB2
Identifiers
Aliases	TOB2, TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5
External IDs	OMIM: 607396; MGI: 1888525; HomoloGene: 9447; GeneCards: TOB2; OMA:TOB2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,446,801 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,742,997 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; paraflocculus of cerebellum; ; gastric mucosa; ; mucosa of paranasal sinus; ; muscle of thigh; ; popliteal artery; ; tibial arteries; ; gastrocnemius muscle; ; right hemisphere of cerebellum; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	ascending aorta; ; aortic valve; ; retinal pigment epithelium; ; ciliary body; ; neural layer of retina; ; brown adipose tissue; ; epithelium of lens; ; medial head of gastrocnemius muscle; ; primary oocyte; ; masseter muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; vitamin D receptor binding; transcription corepressor activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	positive regulation of ossification; female gamete generation; negative regulation of osteoclast differentiation; regulation of gene expression; negative regulation of cell population proliferation; signaling; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	10766
	57259
	ENSG00000183864
	ENSMUSG00000048546
	Q14106
	Q9JM55
	NM_016272
	NM_020507
	NP_057356
	NP_065253
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the TOB2 gene.

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM]