TNNT1

TNNT1
Identifiers
Aliases	TNNT1, ANM, NEM5, STNT, TNT, TNTS, troponin T1, slow skeletal type
External IDs	OMIM: 191041; MGI: 1333868; HomoloGene: 20704; GeneCards: TNNT1; OMA:TNNT1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,149,206 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,519,381 bp
RNA expression pattern
	Top expressed in
	glutes; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; triceps brachii muscle; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; vastus lateralis muscle; ; deltoid muscle; ; tibialis anterior muscle;
	Top expressed in
	soleus muscle; ; plantaris muscle; ; ankle; ; thoracic diaphragm; ; medial geniculate nucleus; ; extraocular muscle; ; intercostal muscle; ; lateral geniculate nucleus; ; internal carotid artery; ; human fetus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	troponin T binding; tropomyosin binding; protein binding; calcium ion binding; calcium-dependent ATPase activity;
Cellular component	cytosol; troponin complex;
Biological process	regulation of muscle contraction; skeletal muscle contraction; slow-twitch skeletal muscle fiber contraction; negative regulation of muscle contraction; transition between fast and slow fiber; muscle filament sliding; muscle contraction; sarcomere organization; cardiac muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	7138
	21955
	ENSG00000105048
	ENSMUSG00000064179
	P13805; Q3B759
	O88346
	NM_001126132; NM_001126133; NM_001291774; NM_003283
	NM_001277903; NM_001277904; NM_011618; NM_001360154
	NP_001119604; NP_001119605; NP_001278703; NP_003274
	NP_001264832; NP_001264833; NP_035748; NP_001347083
	Wikidata
View/Edit Human	View/Edit Mouse

Slow skeletal muscle troponin T (sTnT) is a protein that in humans is encoded by the TNNT1 gene.

The TNNT1 gene is located at 19q13.4 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin T (ssTnT). ssTnT is an ~32-kDa protein consisting of 262 amino acids (including the first methionine) with an isoelectric point (pI) of 5.95. It is the tropomyosin binding and thin filament anchoring subunit of the troponin complex in the sarcomeres of slow twitch skeletal muscle fibers. TNNT1 gene is specifically expressed in slow skeletal muscle of vertebrates, with one exception that dry land toad (Bufo) cardiac muscle expresses ssTnT other than cardiac TnT.