TNFRSF19

TNFRSF19
Identifiers
Aliases	TNFRSF19, TAJ, TAJ-alpha, TRADE, TROY, tumor necrosis factor receptor superfamily member 19, TNF receptor superfamily member 19
External IDs	OMIM: 606122; MGI: 1352474; HomoloGene: 8481; GeneCards: TNFRSF19; OMA:TNFRSF19 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	23,676,104 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	61,283,939 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of thigh; ; bronchial epithelial cell; ; skin of hip; ; mucosa of paranasal sinus; ; skin of abdomen; ; ventricular zone; ; right uterine tube; ; trachea; ; olfactory zone of nasal mucosa;
	Top expressed in
	bronchus; ; calvaria; ; molar; ; main bronchus; ; body of femur; ; epithelium of bronchus; ; maxillary prominence; ; skin of external ear; ; upper jaw; ; vestibular sensory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity; signaling receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; intracellular anatomical structure; plasma membrane;
Biological process	hair follicle development; JNK cascade; apoptotic process; positive regulation of JNK cascade; tissue development; positive regulation of I-kappaB kinase/NF-kappaB signaling; tumor necrosis factor-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55504
	29820
	ENSG00000127863
	ENSMUSG00000060548
	Q9NS68
	Q9JLL3
	NM_001204458; NM_001204459; NM_018647; NM_148957; NM_001354985
	NM_001164155; NM_013869
	NP_001191387; NP_001191388; NP_061117; NP_683760; NP_001341914
	NP_001157627; NP_038897
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.