Toll-like receptor 5

TLR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J0A
Identifiers
Aliases	TLR5, MELIOS, SLE1, SLEB1, TIL3, toll like receptor 5
External IDs	OMIM: 603031; MGI: 1858171; HomoloGene: 20698; GeneCards: TLR5; OMA:TLR5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	223,143,248 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	182,804,010 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; epithelium of bronchus; ; left ovary; ; bronchial epithelial cell; ; right ovary; ; epithelium of lactiferous gland; ; lactiferous duct; ; lower lobe of lung; ; mucosa of paranasal sinus;
	Top expressed in
	granulocyte; ; embryo; ; embryo; ; placenta; ; secondary oocyte; ; liver; ; primary oocyte; ; zygote; ; lip; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; interleukin-1 receptor binding;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	positive regulation of cytokine production; signal transduction; positive regulation of toll-like receptor signaling pathway; defense response to bacterium; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; immune system process; positive regulation of interleukin-8 production; cellular response to mechanical stimulus; innate immune response; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	7100
	53791
	ENSG00000187554
	ENSMUSG00000079164
	O60602
	Q9JLF7
	NM_003268
	NM_016928
	NP_003259
	NP_058624
	Wikidata
View/Edit Human	View/Edit Mouse

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria. It has been shown to be involved in the onset of many diseases, including Inflammatory bowel disease due to the high expression of TLR in intestinal lamina propria dendritic cells. Recent studies have also shown that malfunctioning of TLR5 is likely related to rheumatoid arthritis, osteoclastogenesis, and bone loss. Abnormal TLR5 functioning is related to the onset of gastric, cervical, endometrial and ovarian cancers.