TEF (gene)

TEF
Identifiers
Aliases	TEF, PAR bZIP transcription factor, TEF transcription factor, PAR bZIP family member
External IDs	OMIM: 188595; MGI: 98663; HomoloGene: 31140; GeneCards: TEF; OMA:TEF - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,399,326 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,711,064 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; right frontal lobe; ; nucleus accumbens; ; external globus pallidus; ; parietal lobe; ; postcentral gyrus; ; parotid gland; ; lateral nuclear group of thalamus; ; caudate nucleus;
	Top expressed in
	superior frontal gyrus; ; perirhinal cortex; ; entorhinal cortex; ; olfactory tubercle; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; cerebellar cortex; ; CA3 field; ; muscle of thigh; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; double-stranded DNA binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; rhythmic process; transcription by RNA polymerase II; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	7008
	21685
	ENSG00000167074
	ENSMUSG00000022389
	Q10587
	Q9JLC6
	NM_003216; NM_001145398
	NM_017376; NM_153484
	NP_001138870; NP_003207
	NP_059072; NP_705617
	Wikidata
View/Edit Human	View/Edit Mouse

Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene.

Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter.

It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.