TECR

TECR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DZJ
Identifiers
Aliases	TECR, GPSN2, MRT14, SC2, TER, trans-2,3-enoyl-CoA reductase
External IDs	OMIM: 610057; MGI: 1915408; HomoloGene: 36231; GeneCards: TECR; OMA:TECR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,565,980 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,334,600 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; left testis; ; right testis; ; skin of abdomen; ; skin of leg; ; C1 segment; ; minor salivary glands; ; muscle of thigh; ; right adrenal cortex; ; right frontal lobe;
	Top expressed in
	central gray substance of midbrain; ; cerebellar cortex; ; cerebellar vermis; ; dorsal tegmental nucleus; ; ventromedial nucleus; ; medial vestibular nucleus; ; primary visual cortex; ; supraoptic nucleus; ; lobe of cerebellum; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; protein binding; very-long-chain-acyl-CoA dehydrogenase activity; oxidoreductase activity; very-long-chain enoyl-CoA reductase activity;
Cellular component	cytoplasm; integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; endoplasmic reticulum; nucleus; membrane;
Biological process	fatty acid elongation; fatty acid biosynthetic process; long-chain fatty-acyl-CoA biosynthetic process; very long-chain fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolism; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9524
	106529
	ENSG00000099797
	ENSMUSG00000031708
	Q9NZ01
	Q9CY27
	NM_004868; NM_138501; NM_001321170
	NM_027179; NM_134118
	NP_001308099; NP_612510
	NP_081455; NP_598879
	Wikidata
View/Edit Human	View/Edit Mouse

Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.