Transgelin

TAGLN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UJO
Identifiers
Aliases	TAGLN, SM22, SMCC, TAGLN1, WS3-10, transgelin, SM22-alpha
External IDs	OMIM: 600818; MGI: 106012; HomoloGene: 2398; GeneCards: TAGLN; OMA:TAGLN - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	117,207,464 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,847,356 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; left coronary artery; ; tail of epididymis; ; myometrium; ; urethra;
	Top expressed in
	tunica media of zone of aorta; ; ascending aorta; ; umbilical cord; ; cervix; ; aortic valve; ; seminal vesicula; ; left colon; ; calvaria; ; gallbladder; ; tunica adventitia of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; actin binding; actin filament binding;
Cellular component	cytoplasm;
Biological process	muscle organ development; epithelial cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6876
	21345
	ENSG00000149591
	ENSMUSG00000032085
	Q01995
	P37804
	NM_003186; NM_001001522
	NM_011526
	NP_001001522; NP_003177
	NP_035656
	Wikidata
View/Edit Human	View/Edit Mouse

Transgelin is a protein that in humans is encoded by the TAGLN gene.

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.