TAF8

TAF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WV6, 5FUR
Identifiers
Aliases	TAF8, 43, II, TAF, TAFII-43, TAFII43, TBN, TATA-box binding protein associated factor 8, TAF(II)43
External IDs	OMIM: 609514; MGI: 1926879; HomoloGene: 11094; GeneCards: TAF8; OMA:TAF8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	42,087,461 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	47,813,217 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; apex of heart; ; oocyte; ; monocyte; ; bone marrow cells; ; left ventricle; ; gastrocnemius muscle; ; muscle of thigh; ; tendon of biceps brachii; ; appendix;
	Top expressed in
	granulocyte; ; secondary oocyte; ; thymus; ; zygote; ; yolk sac; ; neural layer of retina; ; ventricular zone; ; primary oocyte; ; tail of embryo; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein heterodimerization activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleus; nucleoplasm; transcription factor TFIID complex;
Biological process	positive regulation of transcription, DNA-templated; multicellular organism development; cell differentiation; regulation of transcription, DNA-templated; regulation of fat cell differentiation; transcription, DNA-templated; maintenance of protein location in nucleus; inner cell mass cell proliferation; snRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	129685
	63856
	ENSG00000137413
	ENSMUSG00000023980
	Q7Z7C8
	Q9EQH4
	NM_138572
	NM_022015; NM_001356290
	NP_612639
	NP_071298; NP_001343219
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.