Staurosporine

Staurosporine
Clinical data
ATC code	none;
Identifiers
	IUPAC name (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-; 10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-; 1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]; benzodiazonin-1-one;
CAS Number	62996-74-1 ;
PubChem CID	44259;
IUPHAR/BPS	346;
DrugBank	DB02010 ;
ChemSpider	40272 ;
UNII	H88EPA0A3N;
ChEBI	CHEBI:15738 ;
ChEMBL	ChEMBL162 ;
PDB ligand	STU (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID30911019 DTXSID6041131, DTXSID30911019 ;
ECHA InfoCard	100.109.946
Chemical and physical data
Formula	C28H26N4O3
Molar mass	466.541 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC;
	InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 ; Key:HKSZLNNOFSGOKW-FYTWVXJKSA-N ;
	(what is this?) (verify)

Staurosporine (antibiotic AM-2282 or STS) is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. It was the first of over 50 alkaloids that were discovered to share this type of bis-indole chemical structure. The chemical structure of staurosporine was elucidated by X-ray crystalography in 1994.

Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The interest in these activities resulted in a large investigative effort in chemistry and biology and the discovery of the potential for anti-cancer treatment.

Clinical data


ATC code	none
Identifiers
IUPAC name (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro- 10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy- 1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7] benzodiazonin-1-one
CAS Number	62996-74-1^Y
PubChem CID	44259
IUPHAR/BPS	346
DrugBank	DB02010^Y
ChemSpider	40272^Y
UNII	H88EPA0A3N
ChEBI	CHEBI:15738^Y
ChEMBL	ChEMBL162^N
PDB ligand	STU (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID30911019 DTXSID6041131, DTXSID30911019
ECHA InfoCard	100.109.946
Chemical and physical data
Formula	C₂₈H₂₆N₄O₃
Molar mass	466.541 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC
InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1^Y Key:HKSZLNNOFSGOKW-FYTWVXJKSA-N^Y
^NY (what is this?) (verify)