Spectrin repeat containing nuclear envelope family member 3

SYNE3
Identifiers
Aliases	SYNE3, C14orf49, NET53, Nesp3, spectrin repeat containing nuclear envelope family member 3, C14orf139, KASH3, LINC00341, NCRNA00341
External IDs	OMIM: 610861; MGI: 2442408; HomoloGene: 17625; GeneCards: SYNE3; OMA:SYNE3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	95,516,650 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	104,976,068 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; parietal pleura; ; synovial membrane; ; trabecular bone; ; synovial joint; ; skin of hip; ; visceral pleura; ; superficial temporal artery; ; pericardium; ; skin of thigh;
	Top expressed in
	neural layer of retina; ; granulocyte; ; zygote; ; lip; ; embryo; ; thymus; ; endothelial cell of lymphatic vessel; ; esophagus; ; embryo; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin filament binding; protein binding; cytoskeletal protein binding;
Cellular component	integral component of membrane; rough endoplasmic reticulum; nuclear outer membrane; nuclear envelope; membrane; meiotic nuclear membrane microtubule tethering complex; nucleus; endoplasmic reticulum; nuclear membrane; cytoplasm;
Biological process	establishment of protein localization to membrane; cytoskeleton organization; regulation of cell shape; nuclear migration; nucleus localization;
	Sources:Amigo / QuickGO
Orthologs
	161176
	212073
	ENSG00000176438
	ENSMUSG00000054150
	Q6ZMZ3
	Q4FZC9
NM_024633; NM_152592; NM_001363692; NM_001384281; NM_001384282;
	NM_001384283; NM_001384284
	NM_001042699; NM_172500
	NP_689805; NP_001350621
	NP_001036164; NP_766088; NP_001390387
	Wikidata
View/Edit Human	View/Edit Mouse

Spectrin repeat containing nuclear envelope family member 3, or Nesprin-3, is a Nesprin-family protein that in humans is encoded by the SYNE3 gene. Nesprin-3 localizes to the outer nuclear membrane, where it is retained by SUN domain-containing proteins. The n-terminus of Nesprin-3 faces the cytoplasm and associates with the cytolinker protein Plectin.