Synapsin I

SYN1
Identifiers
Aliases	SYN1, SYN1a, SYN1b, SYNI, Synapsin I, MRX50, EPILX
External IDs	OMIM: 313440; MGI: 98460; HomoloGene: 48483; GeneCards: SYN1; OMA:SYN1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	47,619,857 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,787,243 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; anterior cingulate cortex; ; Brodmann area 9; ; postcentral gyrus; ; Brodmann area 46; ; superior frontal gyrus; ; Region I of hippocampus proper; ; Amygdala;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; subiculum; ; piriform cortex; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex; ; pontine nuclei; ; primary motor cortex; ; superior colliculus; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; calcium-dependent protein binding; catalytic activity; protein binding; actin binding; ATP binding; protein kinase binding;
Cellular component	cytosol; Golgi apparatus; postsynaptic density; synaptic vesicle; myelin sheath; synapse; synaptic vesicle membrane; presynaptic active zone; axon; cell junction; terminal bouton; dendrite; intracellular organelle; synaptonemal complex; anchored component of synaptic vesicle membrane; presynapse; cytoskeleton; Schaffer collateral - CA1 synapse; extrinsic component of synaptic vesicle membrane;
Biological process	regulation of neurotransmitter secretion; regulation of synaptic vesicle exocytosis; neurotransmitter secretion; chemical synaptic transmission; synaptic vesicle clustering; neuron development; synapse organization; regulation of synaptic vesicle cycle; synaptic vesicle cycle;
	Sources:Amigo / QuickGO
Orthologs
	6853
	20964
	ENSG00000008056
	ENSMUSG00000037217
	P17600
	O88935
	NM_133499; NM_006950
	NM_001110780; NM_013680
	NP_008881; NP_598006
	NP_001104250; NP_038708
	Wikidata
View/Edit Human	View/Edit Mouse

Synapsin I, is the collective name for Synapsin Ia and Synapsin Ib, two nearly identical phosphoproteins that in humans are encoded by the SYN1 gene. In its phosphorylated form, Synapsin I may also be referred to as phosphosynaspin I. Synapsin I is the first of the proteins in the synapsin family of phosphoproteins in the synaptic vesicles present in the central and peripheral nervous systems. Synapsin Ia and Ib are close in length and almost the same in make up, however, Synapsin Ib stops short of the last segment of the C-terminal in the amino acid sequence found in Synapsin Ia.