STEAP3

STEAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VNS, 2VQ3
Identifiers
Aliases	STEAP3, AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde, STEAP3 metalloreductase
External IDs	OMIM: 609671; MGI: 1915678; HomoloGene: 10084; GeneCards: STEAP3; OMA:STEAP3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	119,265,652 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	120,200,435 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; spinal ganglia; ; olfactory zone of nasal mucosa; ; epithelium of bronchus; ; bronchial epithelial cell; ; lactiferous duct; ; trigeminal ganglion; ; triceps brachii muscle; ; biceps brachii; ; muscle of trunk;
	Top expressed in
	lumbar spinal ganglion; ; lip; ; muscle of thigh; ; aortic valve; ; facial skeleton; ; membranous bone; ; ascending aorta; ; Dermatocranium; ; morula; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; protein binding; ferric-chelate reductase (NADPH) activity; metal ion binding; cupric reductase activity; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor; identical protein binding;
Cellular component	integral component of membrane; multivesicular body; endosome; endosome membrane; membrane; integral component of plasma membrane; cytoplasm; plasma membrane;
Biological process	apoptotic process; protein secretion; cell cycle; iron ion homeostasis; copper ion import; ion transport; transferrin transport; regulation of apoptotic process; iron ion import across cell outer membrane;
	Sources:Amigo / QuickGO
Orthologs
	55240
	68428
	ENSG00000115107
	ENSMUSG00000026389
	Q658P3
	Q8CI59
	NM_001008410; NM_018234; NM_138637; NM_182915
	NM_001085409; NM_133186; NM_001379354; NM_001379355
	NP_001008410; NP_060704; NP_619543; NP_878919
	NP_001078878; NP_573449; NP_001366283; NP_001366284
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.

STEAP3 is a metalloreductase, capable of converting iron from an insoluble ferric (Fe³⁺) to a soluble ferrous (Fe²⁺) form.

STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a Di-nucleotide binding domain (Rossmann Fold). This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: 2VNS, 2VQ3 and 2YJZ).