ST8SIA4

ST8SIA4
Identifiers
Aliases	ST8SIA4, PST, PST1, SIAT8D, ST8SIA-IV, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
External IDs	OMIM: 602547; MGI: 106018; HomoloGene: 4147; GeneCards: ST8SIA4; OMA:ST8SIA4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	100,903,282 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	95,667,571 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; blood; ; monocyte; ; trabecular bone; ; cartilage tissue; ; visceral pleura; ; granulocyte; ; bone marrow; ; lymph node; ; amniotic fluid;
	Top expressed in
	fossa; ; median eminence; ; Rostral migratory stream; ; medial ganglionic eminence; ; blood; ; motor neuron; ; substantia nigra; ; suprachiasmatic nucleus; ; superior cervical ganglion; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sialyltransferase activity; sialic acid binding; glycosyltransferase activity; transferase activity; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; membrane; Golgi apparatus;
Biological process	nervous system development; protein glycosylation; N-glycan processing; ganglioside biosynthetic process; oligosaccharide metabolic process; sialylation;
	Sources:Amigo / QuickGO
Orthologs
	7903
	20452
	ENSG00000113532
	ENSMUSG00000040710
	Q92187
	Q64692
	NM_005668; NM_175052
	NM_001159745; NM_009183
	NP_005659; NP_778222
	NP_001153217; NP_033209
	Wikidata
View/Edit Human	View/Edit Mouse

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA4 gene.

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.