ST8SIA1

ST8SIA1
Identifiers
Aliases	ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
External IDs	OMIM: 601123; MGI: 106011; HomoloGene: 2282; GeneCards: ST8SIA1; OMA:ST8SIA1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	22,437,041 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,910,178 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; right hemisphere of cerebellum; ; gonad; ; muscle layer of sigmoid colon; ; prefrontal cortex; ; right adrenal cortex; ; C1 segment; ; testicle;
	Top expressed in
	molar; ; facial motor nucleus; ; medial vestibular nucleus; ; anterior horn of spinal cord; ; deep cerebellar nuclei; ; pontine nuclei; ; dorsal tegmental nucleus; ; substantia nigra; ; proximal tubule; ; habenula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sialyltransferase activity; glycosyltransferase activity; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	glycosphingolipid biosynthetic process; sialylation; protein glycosylation; cellular response to heat; positive regulation of cell population proliferation; sphingolipid metabolic process; lipid metabolism; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6489
	20449
	ENSG00000111728
	ENSMUSG00000030283
	Q92185
	Q64687
	NM_001304450; NM_003034
	NM_011374
	NP_001291379; NP_003025
	NP_035504
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.

In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.